Appropriate amino acids can improve the effectiveness of therapy for hard-to-reach cancers

In the study, the results of which have just been published in the journal "Molecules", scientists have shown that exposing non-small cell lung cancer cells to appropriately selected amino acids can increase the effectiveness of radiotherapy based on local emission of alpha radiation by neutron-activated boron. The so-called BNCT therapy is mainly used to treat particularly sensitive organs, e.g. the brain. The first author of the work is a doctoral student of RadFarm studies conducted at NCBJ.

Original publication:

Investigation of the Impact of L-Phenylalanine and L-Tyrosine Pre-Treatment on the Uptake of 4-Borono-L-Phenylalanine in Cancerous and Normal Cells Using an Analytical Approach Based on SC-ICP-MS,
Emila Balcer i inni,
Molecules 2023, 28(18), 6552; https://doi.org/10.3390/molecules28186552

Animation - How BNCT therapy works: